Increased expression of antiviral defence-related genes (TRIM25, IFNL2, IFNL3 and RSAD2) has provided some understanding into the mechanism of the antiviral effect of lariciresinol-4-β-D-glucopyranoside reported in our previous study, that’s lariciresinol-4-β-D-glucopyranoside treatment may enhance the host intrinsic antiviral immunity against viral infection. The gene discussed is IFNL2; the disease is viral infectious disease.