Since RNF185 might be involved in regulating cGAS-mediated DNA sensing pathway, we further examined the mRNA expression levels of RNF185 as well as ISG15 and OASL-1 (type I IFNs inducible genes) in peripheral blood mononuclear cells (PBMCs) isolated from SLE patients and healthy controls by QPCR analysis. This evidence concerns the gene ISG15 and systemic lupus erythematosus.