MBNL1 and myotonic dystrophy: In many cases DUX4-induced cells with EIF4A3 aggregates appeared to have reduced nuclear staining beyond the aggregates (Fig 5A) suggesting that the majority of EIF4A3 was redistributed to the dsRNA foci, similar to the depletion of MBNL proteins by the mutant nuclear RNA in myotonic dystrophy [32,33].