Here, we demonstrate the expression of OR51B4 in colon cancer cells HCT116 and show that stimulating it with its ligand Troenan inhibits cell proliferation and induces apoptosis in colon cancer cells HCT116 via a calcium induced activation of Phospholipase C (PLC), which leads to the phosphorylation of p38 and a reduced phosphorylation of Akt. This evidence concerns the gene HSPG2 and malignant colon neoplasm.