Not surprisingly, dysregulation of NOTCH1 signaling has been mechanistically linked to the dentate gyrus- and hippocampus-related pathologies present after TBI, including epilepsy via gliosis [71–72], stress and depression via neurogenesis [66, 73–74], and learning and memory deficits via synaptic plasticity [74]. The gene discussed is NOTCH1; the disease is depressive symptom measurement.