The second variant, rs2095044-T (AF = 24.5%), upstream of IL33, is associated with increased eosinophil count (βadj = 0.051 SD; Padj = 3.6×10–27) and is highly correlated with rs2381416 (r2 = 0.94), originally described to associate with eosinophil counts and asthma[9] (Table 1, S3 and S4 Tables). Here, IL33 is linked to asthma.