In liver, SRC-2 cooperates with multiple nuclear receptors, several of which are documented tumor suppressors, including Thyroid Receptor (TR), Estrogen Receptor (ER), Hepatocyte Nuclear Factor 4 alpha (HNF4A), Retinoid X Receptor alpha (RXRA), Farnesoid X Receptor (FXR), and Retinoic Acid Receptor alpha (RARA) [15, 17–20, 24, 64, 65] to coactivate a distinct program of target genes resulting in tumor suppression. This evidence concerns the gene NCOA2 and neoplasm.