Mmp12, part of the inflammatory matrix metalloproteinase family, was up‐regulated in the SCN 143‐fold during diabetes but unaffected by pioglitazone treatment (Table S2), supporting our previous study which demonstrated Mmp12 up‐regulation in the SCN of leptin‐deficient BTBR ob/ob mice 36. This evidence concerns the gene MMP12 and diabetes mellitus.