Owing to its functional importance in the process of protein maturity, the abnormal expression of TUSC3 may be the critical cause of relative diseases, such as ARMR, oral squamous cell carcinoma, ovarian cancer, et al. It is believed that TUSC3 may be used in the future as a helpful biomarker and as a therapeutic target in the diagnosis and therapy of ARMR and related cancers. This evidence concerns the gene TUSC3 and cancer.