EFNB2 and Hypertension: Indeed, we have previously revealed that 5 single nucleotide polymorphisms (SNPs) in the EFNB2 gene are associated with hypertension in male patients in the ADVANCE (Action in Diabetes and Vascular Disease: Peterax and Diamicron MR Controlled Evaluation) study30, a clinical trial in type 2 diabetes (T2D)32.