Similarly, we found the tumour development 8 weeks after orthotopic transplantation of HPDE cells harbouring genomic mutations in CDKN2A, SMAD4 and TP53 and expressing KRASG12V (HPDEKCST; Fig. 6f and Supplementary Table 5), indicating that overexpression of ERBB2 is dispensable for invasive tumour development in this model. The gene discussed is SMAD4; the disease is neoplasm.