The incidences of all-/high-grade pneumonitis in the two dosage subgroups were 4.57%/0.89% for low-dose groups of nivolumab, 3.27%/1.81% for high-dose group of nivolumab (both P > 0.05), and 3.55%/1.93% for low-dose group of pembrolizumab, 2.14%/1.64% for high-dose group of pembrolizumab (both P > 0.05), respectively, implying a much broader range of feasible and secure dosages in the anti-PD-1 treatment. The gene discussed is PDCD1; the disease is pneumonitis.