PCA3 and benign prostatic hyperplasia: A recent study has indicated that PCA3 expression can be considered as a reliable marker for PCa detection based on the fact that a significantly increased PCA3 expression was observed in patients with PCa compared to healthy individuals and patients with benign prostatic hyperplasia (10.64- and 7.17-fold, respectively), while PCA3 expression in both urine and blood samples was not different between control and BPH groups [52].