Incorporation of TMPRSS2:ERG test improves the sensitivity of PCA3 from 68% to 76% in PCa detection, and greatly increases the predictive value of European Randomized Study of Screening for Prostate Cancer (ERSPC) risk calculator for predicting biopsy, Gleason score (p < 0.001), and clinical tumor stage (p = 0.023) [56]. Here, PCA3 is linked to Familial prostate cancer.