Furthermore, Neveu et al. [41] have introduced PCA3 promoter into a new transcriptional amplification system, namely the 3-Step Transcriptional Amplification System (PCA3-3STA), and cloned it to adenovirus, which provides a superior amplification of the PCA3 promoter activity, and has a higher specificity for PCa cells compared to benign primary prostate epithelial cells or non-PCa cells. This evidence concerns the gene PCA3 and posterior cortical atrophy.