GAS5 and benign prostatic hyperplasia: In a recent study of exosomes conducted with urinary samples from 30 PCa patients and 49 BPH patients, Isin et al. have demonstrated a significant difference in the exosomal lincRNA-p21, but not GAS5 levels between PCa and BPH patients, suggesting that exosomal lncRNA-p21 levels may act as a promising biomarker for the detection of PCa and its distinction from benign disease [81].