For example, inhibition of the bile salt export pump (BSEP/ABCB11) at the canalicular membrane of hepatocytes may lead to cholestasis [49]; inhibition of OATP1B1 and OATP1B3 at the basolateral membrane of hepatocytes may lead to hyperbilirubinemia [50]. This evidence concerns the gene SLCO1B3 and Hyperbilirubinemia.