NFE2L2 and obesity due to melanocortin 4 receptor deficiency: In the present study, an animal model of T2DM with leptin receptor defect was used to demonstrate that Zn deficiency significantly exacerbates obesity-induced cardiac oxidative damage, inflammation, and fibrosis in diabetes, effects associated with significantly decreased expression of Nrf2 and the downstream antioxidants NQO-1 and CAT.