In the present study, therefore, we tested the following hypotheses: (1) Zn deficiency may accelerate the development and progression of DCM in T2DM; (2) mechanistically, Zn deficiency may impair the expression and function of Nrf2, leading to an exacerbation of diabetes-induced pathogenic process in cardiomyopathy. The gene discussed is NFE2L2; the disease is type 2 diabetes mellitus.