Proteins involved, detected in a very large-scale co-precipitation study [95], with some of the interactions that were only predicted, are NME2 (nucleotide diphosphate kinase, involved in tumorigenesis), EZR (ezrin), the aspartate aminotransferase GOT1 (or more probably GOT2, its mitochondrial equivalent); ESD (esterase D, a marker of retinoblastoma), AKR1B1 (reducing aldehydes and ketones), ALDH1B1, CBS, SOD1 and SOD2, PDXK (pyridoxal kinase), UAP1L1, UQCRFS1, PREP, PGM1, PITPNB, PPID and ADSS, the biological relevance of which is still difficult to assess. The gene discussed is PDXK; the disease is retinoblastoma.