The function of Bax during ischemia has been well documented, and plays a crucial role in mitochondrial-dependent apoptosis (Bax, cytosolic Cyto C, activated caspase-9 and activated caspase-3) via inducing mitochondrial permeabilization and therefore the release of apoptogenic factors [25,36,37]. The gene discussed is CASP3; the disease is ischemia.