AKT2 and myocardial ischemia: It showed that inhibition of AKT2 activity induces silencing of both the internal and external apoptotic signaling pathway, while upon the disruption of MOMP, mitochondrial-dependent cell death was provoked via conducting AIF and EndoG nucleus translocation and thereafter DNA degradation, thus supporting the conclusion that there is a switch to the unique mitochondrial-dependent DNA degradation pathway during cardiac ischemia when AKT2 is inhibited.