Sixth, we confirmed that A549 cell migration into Matrigel was more potently inhibited by the VCAM-1-D6 huMab than by a blocking antibody to the VCAM-1-D1 domain (51-10C9), demonstrating the specificity of the role of VCAM-1-D6 in lung cancer cell migration into Matrigel. This evidence concerns the gene VCAM1 and lung carcinoma.