KLK3 and neoplasm: Lower PSA is associated with a reduced rate of tumor growth in vitro and lower tumor weight in vivo.[8,21] These previous findings support the correlation between the TC genotype of rs1058205 and reduced serum PSA in both PCa patients and healthy control subjects and the association between the TT genotype and increased PCa risk that were observed in our present study and relevant previous studies by other investigators.[20]