Previous studies have shown that rs1058205, a tag SNP in the 3′ untranslated region of KLK3 at the 19q13.33 locus, was associated with lower serum PSA levels in Swedish and African-American men,[12,13] and that the TT genotype of rs1058205 was associated with reduced PCa aggressiveness in Caucasian American men based on Gleason scoring,[13] which suggests that sequence variation at rs1058205 may protect against PCa in at least some populations. This evidence concerns the gene KLK3 and posterior cortical atrophy.