Previous studies have shown that rs1058205 was associated with lower serum PSA in Swedish and African American men,[12,13] and that the TT genotype of rs1058205 was associated with reduced PCa aggressiveness in Caucasians.[13] Penney et al[20] showed that the C allele of rs1058205 was significantly associated with lower PSA and a reduced risk of PCa in predominantly Caucasian American control subjects and that detection bias resulting from the use of PSA-based screening for clinical diagnosis could not fully explain the association observed between variation at rs1058205 and the risk of PCa. Here, KLK3 is linked to posterior cortical atrophy.