Eventually, only a few of the patients we analyzed had clinically relevant AAb profiles that could raise high suspicion for an underlying autoimmune disease (e.g., ANAs with titers ≥1:160 specifically reacting with dsDNA or ENAs; aCL or anti-β2GP1 antibodies with levels ≥40 MPL/mL, GPL/mL or U/mL; ANCAs with anti-PR3 or anti-MPO specificity). The gene discussed is APOH; the disease is autoimmune disease.