LGI1 and Hyponatremia: However, the low tumor detection percentage and relatively higher percentage of patients with hyponatremia that are found in LE associated with anti-LGI1 antibodies are similar to those found in LE associated with anti-NAE antibodies (Table 3).[5,6] Moreover, 4 of the 19 patients in the present study had anti-LGI1 antibodies in addition to anti-NAE antibodies, suggesting that LE associated with antibodies to LGI1 should be excluded in patients with LE and anti-NAE antibodies.