CD4 and neoplasm: Therefore, the elevated CD3+ level could increase the corresponding immune function of the body.[24] CD4+ cell, which could secret a large number of cytokines and assist CD8+ to kill tumor cells, plays a crucial role in the antitumor immunity.[25] When the cellular immune function was recovered or improved after the surgery, CD4+ was increased first, followed by an increase of CD4+/CD8+ cells.