In patients with psoriasis, NKp44+ ILC3s are increased in both lesional and non-lesional skin and NKp44− ILC3s have the potential to differentiate to NKp44+ ILC3s in response to stimulation of IL-1β and IL-23 (Teunissen et al., 2014; Villanova et al., 2014). Here, NCR2 is linked to psoriasis.