However, another study confirmed that dysfunctional PV+ neurons contribute to social phenotypes whereas SOM+ neurons do not by heterozygous deletion of the mouse version of the gene underlying Dravet syndrome, Scn1a (loxP/+), in either type of neuron using PV-cre and SOM-cre, respectively [40]. Here, GRHL3 is linked to encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy.