IBC patients showed mutations in the following: TP53 (22/32; 69%), RB1 (5/32; 16%), PIK3CA (4/32; 13%), BRCA1 (3/32; 9%), BRCA2 (3/32; 9%), and Notch1 (3/32; 9%). The gene discussed is RB1; the disease is inflammatory breast carcinoma.