The RA associated HLA-DRB1 alleles that were significantly more present in the Tunisian samples compared to those in the French samples were, by order of Odds Ratios, HLA-DRB1∗04:05 (OR = 2.15), HLA-DRB1∗13 (OR = 2.39), HLA-DRB1∗10 (OR = 3.65), HLA-DRB1∗03 (OR = 4.17), and HLA-DRB1∗04:06 (OR = +∞). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.