INS and type 2 diabetes mellitus: Increasing evidences demonstrated that patients with T2D in Chinese population are quite different from the Western countries, such as the thrifty gene carried in Chinese population [19], the different pattern of intake of nutrients and life style, the good responsiveness to oral antidiabetic agents (e.g., α-glucosidase inhibitor and sulfonylureas), the lower insulin dose requirements, the higher remission rate of short intensive insulin therapy [20], and the lower BMI and the less waist circumferences compared to whites [21].