Subjects with T2DM plus the Metabolic Syndrome homozygous for the allele 4G/4G had the highest PAI-1 plasma levels (56.7 (48.5–73.7) ng/mL), followed by the heterozygous allele 4G/5G (52.7 (43.9–70.2) ng/mL), with the lowest concentration for the homozygous allele 5G/5G (50.1 (39.1–63.3) ng/mL), but without significant statistical difference between the three genotypes by ANOVA test (4G/4G versus 5G/5G, p = 0.58; 4G/5G versus 5G/5G, p = 0.39; 4G/4G versus 4G/5G, p = 0.98) (Figure 2(a)). This evidence concerns the gene SERPINE1 and metabolic syndrome.