The genotype distribution of 4G/5G polymorphism of PAI-1 gene in the group with T2DM plus the Metabolic Syndrome was 4G/4G, 11.6% (n = 25), 4G/5G, 48.4% (n = 104), and 5G/5G, 40% (n = 86), with an allelic frequency of 35.8% (n = 154) for the allele 4G (Table 2). This evidence concerns the gene SERPINE1 and metabolic syndrome.