Components of the Metabolic Syndrome were much more determinant in PAI-1 variability than the 4G/5G polymorphism, with a standardized correlation coefficient (β) statistically meaningful for hypertension: β = 0.18 (0.35 to 0.012), p = 0.03; β = −0.16 (−0.33 to −0.01 for NL HDL-c), p = 0.05; and β = 0.15 (0.01 to 0.33), p = 0.05, for NL triglycerides. The gene discussed is SERPINE1; the disease is metabolic syndrome.