SEPTIN9 and colorectal carcinoma: A great number of blood-based biomarkers for the early detection of CRC have been reported [8], but only one has been approved by the U.S. Food and Drug Administration so far: the Epi proColon test (Epigenomics AG, Berlin, Germany), that measures the methylation of the SEPT9 gene in circulating cell-free DNA in blood, detected CRC with a sensitivity (specificity) of 48% (92%) in a screening setting [9].