TLR4 and infection: Adult C57BL/6 mice deficient for toll-like receptor 4 (TLR4) or myeloid differentiation factor 88 (MyD88) (44), μMT mice devoid of B cells (44) as well as C57BL/6 mice deficient for the decay-accelerating factor (DAF)-1ko (37), were shown to die after infection with L. interrogans serovar Copenhageni.