Furthermore, POMC-specific deletion of SHP2 results in mild obesity and increased susceptibility to DIO (121, 122), while female mice expressing a constitutively active form of SHP2 in the brain are resistant to DIO (123), supporting the role for SHP2 in the control of energy homeostasis. The gene discussed is PTPN11; the disease is obesity due to melanocortin 4 receptor deficiency.