The D2R-NMDA heteroreceptor complexes may therefore be at the heart of the dysregulation of the anti-reward neurons in schizophrenia together with the perisynaptic A2AR-D2R-mGluR5 heteroreceptor complexes where inhibitory D2R signaling becomes preferred by the allosteric receptor–receptor interactions. This evidence concerns the gene DRD2 and schizophrenia.