DRD2 and schizophrenia: Understanding these D2R heteroreceptor complexes and their dysfunction in schizophrenia can lead to new strategies for its treatment and for avoiding side-effects of antipsychotics known to mainly act as D2R antagonists (Seeman, 2010), including a way to optimize combined treatment or single use of heterobivalent drugs targeting the D2R heteroreceptor complexes in schizophrenia.