Transport rates of mitochondrial aspartate/glutamate carrier (AGC) were higher in temporo-cortical gray matter. In addition, expression of AGC1, cytochrome c oxidase activity, and oxidized mitochondrial proteins were increased. However, variants of the AGC1-encoding SLC25A12 gene were not correlated with AGC activation or autism phenotype. Here, SLC25A12 is linked to autism.