Peripheral nerve injury leads to a significant decrease expression of voltage-gated potassium (Kv) channels, such as Kv1.2, encoded by Kcna2, at both transcriptional and translational levels in the injured DRG, which participate in neuropathic pain genesis6, 7, 8, 9, 13, 14, 15, 16, 17, 18. Here, KCNA2 is linked to peripheral nerve injury.