CHUK and infection: While this miRNA mutant virus recapitulates WT levels of IKKα and IKKβ in infected cells, it also reduces proinflammatory cytokine levels to those observed during WT infection (Fig. 9), indicating that miR-US5-1 and miR-UL112-3p targeting of IKKα and IKKβ, and not other targets of these miRNAs, is primarily responsible for the phenotype.