As seen in Fig. 6C and D, infection with the miR-US5-1/miR-UL112-3p mutant virus resulted in increased accumulation of IL-6 and CCL5 transcripts, respectively, compared to WT-infected cells in the presence of negative-control miRNA; however, preexpression of miR-US5-1 and miR-UL112-3p was able to restore cytokine transcript accumulation in miRNA mutant virus-infected cells to levels observed during WT infection and similar to those observed in infection in the presence of siRNAs targeting IKKα and IKKβ. This evidence concerns the gene CCL5 and infection.