MMP14 and cancer: MT1-MMP is expressed on the cell surface and promotes cellular migration and invasion of different cell types, including various cancer cells, endothelial cells, fibroblasts, mesenchymal stem cells, B-cells, T-cells, monocytes/macrophages, osteoclasts, and epithelial cells, by degrading pericellular extracellular matrix (ECM) to make a migration path (1, 2).