GDF11 and cardiac hypertrophy: Indeed, several reports have emerged in response to these data, indicating non‐specific GDF11 detection methods (Egerman et al, 2015; Rodgers & Eldridge, 2015; Smith et al, 2015), irreproducibility of GDF11 decline with age (Egerman et al, 2015; Rodgers & Eldridge, 2015), prevention of cardiac hypertrophy (Smith et al, 2015), and the enhancement of muscle regeneration (Egerman et al, 2015; Hinken et al, 2016).