Mutations in 11 genes, including ABCC8, KCNJ11, GLUD1, GCK, HADH, UCP2, SLC16A1 (MCT1), HNF4A, HNF1A (6), HK1 (7), and PGM1 (8) are known to cause CHI. The gene discussed is ABCC8; the disease is congenital isolated hyperinsulinism.