Both SLC2A9 and ABCG2 are associated with hyperuricaemia in the general population, and the lack of an observed association between tophaceous disease and SLC2A9 rs11942223 suggests that the association between ABCG2 and tophaceous disease in people with gout are not entirely due to effects on serum urate concentrations. This evidence concerns the gene ABCG2 and hyperuricemia.