Analysis of the combined cohort of 741 breast cancer patients that was used in the design of the IRGS [32] (herein termed cohort #1), revealed that high DCYTB expression (values above the mean) was an excellent overall predictor of distant metastasis-free survival (p = 1.6e-11, n = 741, log-rank test; Fig. 1a). Here, CYBRD1 is linked to breast cancer.