Interestingly, a significant positive correlation between Notch-1 and Syndecan-1 mRNA levels (r = 0.793, P = 0.001) (Fig. 7b) and between Notch-3 and Syndecan-1 mRNA levels (r = 0.819, P = 0.001) (Fig. 7c) did exist in carcinoma tissues of IBC. This evidence concerns the gene NOTCH3 and carcinoma.