First, MEIS1 expression is reduced in ccRCC tissues or cell lines; second, overexpression of MEIS1 suppresses proliferation, colony formation and anchorage independent growth of ccRCC cells; third, MEIS1 overexpression induces cell cycle G1/S arrest and non-apoptotic cell death of ccRCC cells. This evidence concerns the gene MEIS1 and nonpapillary renal cell carcinoma.