HCRT and migraine disorder: Specifically, Orexin A and Orexin B are secreted by hypothalamic neuronal cells and modulate feeding control: administered centrally in rats they increase food intake [34–36]; orexin A levels seems to be elevated in the cerebrospinal fluid of migraine patients and in chronic daily headache sufferers, probably due to orexin resistance or disruption in orexin receptors [37] and animal and human data support a role for orexins in pain processing [38].