The link between migraine and obesity is multifactorial: inflammatory mediators such as the calcitonin gene-related protein (CGRP), neurotransmitters such as serotonin, peptides such as orexin, and adipocytokines such as adiponectin and leptin play a role both in feeding and migraine physiopathology and could explain the common pathogenesis [13]. Here, HCRT is linked to migraine disorder.