TNFSF11 and periodontal disorder: Recently, in vivo studies have demonstrated that β-glucans from S. cerevisiae present regulatory activity toward metabolism [24] and also modulate the expression of cycloxygenase-2 (COX-2), receptor activator of nuclear factor kappa-B ligand (RANK-L), and osteoprotegerin (OPG), decreasing alveolar bone loss caused by induced periodontal disease (ligature) in normal and diabetic animals [25].