PROK2 and colitis: Regarding the PK2 long isoform (PK2L) mRNA (Fig 6), two-way ANOVA showed a main effect of colitis (F1,13 = 594.2, p<0.0001), of CORT treatment (F1,13 = 505.6, p<0.0001) and an interaction between the two factors (F1,13 = 479.7, p<0.0001).