Since PP2A expression is down regulated in the peripheral blood monocytes of patients with severe, glucocorticoid-resistant asthma [12,13,25], the same group reported to have increased IFNγ production, we hypothesized that decreased PP2A expression might promote dysregulation of FoxO1, subsequently causing aberrant IFNγ production in Tregs cells and potentially greater overall dysfunction. The gene discussed is PTPA; the disease is asthma.