Thirty‐six mutated genes (FDR < 0.05) were enriched across the NF1 mutants in a mutation frequency range of 5–36% (Table S4) including the previously described RASopathy genes PTPN11 and RASA2 (11), as well as another RAS domain‐containing gene RASSF2. This evidence concerns the gene RASSF2 and RASopathy.