APC and adenosarcoma: In addition, the Wnt signaling pathway was significantly altered in adenosarcomas, which harbored, among other alterations in Wnt pathway‐related genes (Barker et al., 2001), homozygous deletions of APC (1/19, 5%) and SMARCA4 (1/19, 5%) and nonsynonymous mutations affecting AXIN1 (1/19, 5%) and AXIN2 (1/19, 5%) (Fig. 5B).