Although we observed no significant differences in the total KA dose required to obtain a continuous motor seizure (t-test, t20=0.3043, P=0.7641) and onset of status epilepticus (t-test, t20=0.1743, P=0.8634) between wild-type and neuropsin-KO mice (Supplementary Table 1), the severity of the seizures in neuropsin-KO mice after KA injection was significantly greater than that in wild-type mice only at the 4 h time point (n=11 mice, two-way ANOVA, F(1,20)=5.744, P=0.046; Figure 2). Here, KLK8 is linked to status epilepticus.