PDE10A and schizophrenia: Thinning of these brain areas has been reported early in the schizophrenia illness progression and has been hypothesized to be part of the early pathophysiological process.18, 47 But this could also be a result of later dynamic cerebral reorganization in patients with schizophrenia.48 The correlation to frontal cortical thickness highlights the importance of PDE10A in cortico-striatal interactions, suggesting that striatal functional alterations and frontal cortical thinning are part of the same underlying pathophysiology.